Design of novel tryptamine-based SDHI fungicides inspired by rice phytoalexins: Antifungal activity evaluation and molecular mechanism

Key Points

• Novel tryptamine-based fungicides show significant antifungal activity against various pathogens, indicating effectiveness.
• In vitro analysis demonstrates a 75% reduction in fungal growth for the most effective compound, highlighting its potential utility.
• Targeted molecular mechanisms reveal the action of these fungicides on fungal cell metabolism and resistance pathways.
• Broad implications suggest these fungicides could enhance crop protection strategies and reduce agricultural reliance on existing chemicals.