Cathepsin B mediates HDAC inhibitor-induced epithelial-mesenchymal transition in lung cancer cells

Key Points

• Epithelial-mesenchymal transition is significantly increased by HDAC inhibitors, indicating critical adaptive pathways in lung cancer.
• Cathepsin B acts as a mediator, influencing the response of lung cancer cells to HDAC inhibitors through specific molecular interactions.
• The investigation utilizes a series of in vitro experiments to explore the relationship between cathepsin B and HDAC inhibitor effects on lung cancer cells.
• Findings underscore the potential of targeting cathepsin B to enhance therapeutic strategies for lung cancer, highlighting its role in treatment sensitivity.