L17E cell-penetrating peptide enhances intranasal delivery of IgG to the cerebrospinal fluid in mice

Key Points

• Enhanced intranasal delivery of IgG was observed using the L17E cell-penetrating peptide, improving CNS access.
• The administration led to a notable increase in IgG levels within cerebrospinal fluid, identified through bioanalytical methods.
• The analysis assessed the absorption and distribution of IgG in a preclinical mouse model, enhancing our understanding of peptide-mediated delivery.
• This method may enable improved therapeutic strategies for conditions involving the central nervous system, pending further validation.