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N‑acetylcysteine for post-ERCP pancreatitis prophylaxis: A systematic review and meta-analysis | Synapse
March 3, 2026
N‑acetylcysteine for post-ERCP pancreatitis prophylaxis: A systematic review and meta-analysis
AE
Anshuman Elhence
PM
Prabhaker Mishra
Sanjay Gandhi Post Graduate Institute of Medical Sciences
PR
Praveer Rai
Key Points
N-acetylcysteine shows promise in reducing post-ERCP pancreatitis incidence.
The meta-analysis includes data from multiple studies indicating efficacy at various doses.
Observational analysis of diverse trial data demonstrates significant reduction in pancreatitis risks.
Further validation needed in larger trials to confirm effectiveness and safety in clinical practice.
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Elhence et al. (Sat,) studied this question.
synapsesocial.com/papers/69a75a34c6e9836116a1fc6e
https://doi.org/https://doi.org/10.1007/s12664-025-01909-x