Intrinsic connectivity patterns of striatal subfields predict individual dimensions of psychopathology and are associated with cholinergic and serotonergic neurotransmission in schizophrenia

Key Points

• Intrinsic connectivity patterns predict individual dimensions of psychopathology in schizophrenia, highlighting their potential role in mental health outcomes.
• Cholinergic and serotonergic neurotransmission are significantly associated with these connectivity patterns, suggesting a biochemical link to psychopathology.
• This analysis utilized brain imaging techniques to explore connectivity in specific striatal subfields, focusing on their relevance to clinical symptoms.
• Findings may enable targeted interventions by enhancing the understanding of specific neurotransmitter roles in schizophrenia.