Mitochondrial-derived peptides (Humanin, MOTS-c, and SHLP2) protect pancreatic islet cells and delay the onset and progression of type 2 diabetes mellitus in mice

Key Points

• Mitochondrial-derived peptides show protective effects on pancreatic islet cells, delaying type 2 diabetes onset.
• The specific peptides, Humanin, MOTS-c, and SHLP2, were effective in a mouse model, preventing metabolic disturbances.
• The study utilized a mouse model to examine how these peptides influence diabetes progression.
• Findings support the potential of mitochondrial-derived peptides as therapeutic agents for type 2 diabetes management.