Metallo-hydrazones of pyridine–thiophene derivatives: structure–function insight and anticancer evaluation of Co( iii ), Ni( ii ), Cu( ii ), and Zn( ii ) complexes

Key Points

• Anticancer evaluation shows significant effects of metal-based agents on cellular processes.
• Metal complexes, including Co(iii), Ni(ii), Cu(ii), and Zn(ii), demonstrate varied efficacy in preclinical tests.
• Analysis of metallo-hydrazones highlights their structural importance for enhancing therapeutic outcomes.
• Results suggest that further exploration of these complexes could lead to new cancer treatments.