Abstract Optically pure alkynyl-containing molecules represent highly versatile synthons in organic synthesis. Herein, we report a Pd/pGlu-catalyzed enantioselective C–H alkynylation of nparacyclophanes. This method provides efficient access to a diverse range of alkynylated nparacyclophanes in high yields with excellent enantioselectivities. Additionally, a cyclophane-based bifunctional thiourea catalyst was synthesized and exhibited promising activity in asymmetric Michael additions. Thermal epimerization studies were further conducted to elucidate the correlation between conformational stability and structural parameters.
Zhao et al. (Tue,) studied this question.