Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification

Key Points

• Endothelial cell senescence is attenuated by stabilizing GSTM2 with HCY-NBD.
• GSTM2 stabilization through cys174 sulfenylation shows a significant reduction in oxidative stress levels.
• Assessment using high glucose conditions reveals increased calcification in endothelial cells.
• This suggests a promising intervention for preventing complications in high glucose environments.