Thrombomodulin facilitates melanoma progression via FAK- and ezrin-mediated phenotypic plasticity

Key Points

• Tumor progression is facilitated by thrombomodulin, enhancing melanoma cell plasticity through specific pathways.
• Key findings indicate that targeting thrombomodulin could potentially suppress melanoma growth effectively.
• Analysis focused on FAK and ezrin-mediated mechanisms within melanoma cells, establishing their role in tumor dynamics.
• Highlights the need for further exploration into therapeutics that can disrupt cancer cell plasticity effectively.

Abstract