March 3, 2026Open Access

Metastatic and recurrent salivary gland carcinoma: clinical characteristics and comprehensive molecular profiling at a tertiary care center

Key Points

Comprehensive genomic profiling reveals modest impact on treatment selection and response in salivary gland carcinoma.
HER2 immunohistochemical 2+ expression observed in multiple subtypes, indicating potential for targeted therapies.
Assessment of molecular markers highlights their relevance in optimizing treatment choices for patients with SDC.
Implications suggest that more patients may benefit from TDxd as a treatment option based on molecular profiling.

Abstract

The impact of immunohistochemical or molecular markers on treatment selection and response was most pronounced in SDC. HER2 IHC2 + expression was observed across multiple subtypes, indicating that TDxd may represent a potential treatment option for more pts than previously anticipated. The impact of comprehensive genomic profiling on targeted treatment options is currently still modest.

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Cite This Study

Rordorf et al. (Tue,) studied this question.

synapsesocial.com/papers/69a75ad9c6e9836116a2137a https://doi.org/https://doi.org/10.1007/s00432-026-06426-8

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