Complement contributes to ICI-triggered sialadenitis and predicts ICI efficacy

Key Points

• Sialadenitis is linked with complement activation, suggesting a critical role in immune response.
• The study shows that higher complement levels correlate with better ICI efficacy in patients.
• Analysis of biomarkers highlights the potential for complement as a predictor of therapeutic outcomes.
• These findings may enable more targeted interventions for patients undergoing immunotherapy.