STAT1/SLC31A1 signaling promotes diabetic retinopathy progression by mediating cuproptosis-induced M1 polarization in microglial cells

Key Points

• Diabetic retinopathy progression is promoted by STAT1 and SLC31A1 signaling pathways.
• Key evidence shows that cuproptosis in microglial cells leads to M1 polarization, increasing inflammatory response.
• Analysis of microglial function reveals the role of cuproptosis in diabetes-related complications.
• These findings highlight potential therapeutic targets for managing diabetic retinopathy and reducing inflammation.