Transcriptional and epigenetic control of human naïve CD8+ T cell activation

Key Points

• CD8+ T cell activation relies on a core set of transcription factors and genes.
• Identification of key regulators includes factors that control gene expression involved in T cell response.
• Assessment of the molecular mechanisms provides insights into the pathways critical for initial T cell activation.
• These findings may enable the development of enhanced adoptive cell therapies for more robust immune responses.