Disease-driven restructuring of the gut microbiome underlies inflammatory bowel disease dysbiosis

Key Points

• Dysbiosis in IBD patients features enriched inflammation-related pathways and reduced metabolic flexibility.
• Patients exhibit alterations in gut microbiota that correlate with disease severity and inflammation levels.
• Assessment using comparative microbiome analysis highlights shifts in microbial composition linked to IBD.
• These findings may enable targeted therapies to restore gut microbiome balance and alleviate inflammation.