March 3, 2026

Highlights of Pd-Catalyzed Reactions of Alkynes Involving C-H Functionalization: Synthesis of Acyclic, Carbo- and Heterocyclic Compounds Installed with Alkyne Unit

SBSubhankar BodakIndian Institute of Science Education and Research Mohali PSPrashant ShuklaIndian Institute of Science Education and Research Mohali AKAmit KumarIndian Institute of Science Education and Research Mohali

Key Points

C-H functionalization enables the creation of diverse carbo- and heterocyclic compounds, enriching synthetic methodologies.
Palladium catalysis plays a crucial role in facilitating multiple reaction pathways involving alkynes.
Key reactions include annulation and various alkylation techniques, expanding the utility of alkynes in synthesis.
The findings underscore continuous advancements in C-H functionalization, pointing towards new applications in biologically active compounds.

Abstract

The review discusses the utility of C-H functionalization approaches involving alkynes, which act as multifaceted coupling partners due to their unsaturation property, small size, and potential to participate in multiple reaction pathways, such as annulations, alkylation, alkenylation, and alkynylation. The review emphasises the investigation of palladium catalysis for these transformations. It highlights the developments in Pd-catalysed C-H functionalization-based synthesis of simple and complex carbo- and heterocyclic compounds, as well as biologically active and alkynyl-functionalized molecules.

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Cite This Study

Bodak et al. (Tue,) studied this question.

synapsesocial.com/papers/69a75b18c6e9836116a21c9d https://doi.org/https://doi.org/10.1055/a-2796-9980

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