March 3, 2026Open Access

Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms

Key Points

Cardiovascular risk significantly increases due to mitochondrial dysfunction in women with PCOS, underscoring urgent health concerns.
Key mechanisms include systemic inflammation and mitochondrial dysfunction, both of which require targeted intervention approaches.
Assessment of biomarkers alongside specific phenotypes may lead to improved interventions and overall cardiovascular outcomes.
This highlights the need for future research to focus on identifying effective therapies for better health in women with PCOS.

Abstract

Mitochondrial dysfunction and inflammation are interdependent mechanisms that contribute substantially to cardiovascular risk in women with PCOS. Targeting mitochondrial dysfunction and systemic inflammation presents a promising therapeutic strategy for reducing cardiovascular morbidity in PCOS. Future research should emphasize phenotype-specific interventions, biomarker discovery, and translational trials to improve long-term reproductive and cardiovascular outcomes.

Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms

Key Points

Abstract

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