CXCR2 + Neutrophils Drive Neutrophil Extracellular Traps Formation and Exacerbate Pulpitis in Rats: An In Vitro and In Vivo Laboratory Investigation

Key Points

• CXCR2+ neutrophils enhance inflammation in pulpitis, leading to increased NETs formation.
• Blocking CXCR2 reduces inflammation significantly and promotes dentine repair, indicating its therapeutic value.
• This investigation combines in vitro assessments with in vivo models using rats to confirm findings in a biological context.
• Understanding the role of CXCR2+ neutrophils may yield new strategies for managing pulpitis and improving dental health.