Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders

Key Points

• Polygenic risk scores significantly predict obsessive-compulsive symptoms in pediatric populations with mental disorders.
• Key evidence indicates a strong association, where higher risk scores correlate with increased symptom severity in samples diagnosed clinically.
• Observational analysis assesses the mediating effects of genetic factors on symptom manifestation among youth identified with mental disorders.
• Findings underscore the necessity of incorporating genetic risk into understanding and addressing pediatric mental health challenges.