In silico prediction, molecular docking and simulation of natural flavonoid apigenin and xanthoangelol E against human metapneumovirus

Key Points

• In silico prediction reveals promising binding affinities for apigenin and xanthoangelol E against human metapneumovirus.
• Binding affinities of apigenin reached 8.5 kcal/mol, indicating strong molecular interactions.
• Molecular docking simulations were utilized to assess interactions between natural flavonoids and viral proteins.
• Research supports the potential use of flavonoids as antiviral agents in future studies to combat metapneumovirus.