March 3, 2026

Clarifying the immunoglobulin light chain variable gene usage in Chinese patients with renal AL amyloidosis

Key Points

Severe kidney structural damage is linked to IGLV1 gene usage, impacting renal function significantly.
Full nephrotic syndrome occurs more frequently in patients with IGLV6-57, suggesting a distinct phenotype.
Assessment highlights the connection between specific immunoglobulin genes and clinicopathological features of AL amyloidosis.
Findings indicate that IGLV1-51 usage may serve as a predictor of poor renal survival, warranting further investigation.

Abstract

The IGVL gene usage is associated with distinct clinicopathological features in renal AL amyloidosis, IGLV6-57 is linked to a higher frequency of full nephrotic syndrome, IGKV1 is associated with severe kidney structural damage and hepatic tropism, and IGLV1-51 potentially predicts poor renal survival.

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Discussion

Authors

Shuang Wang

Dan-yang Li

Journals

Amyloid

Actions

Institutions

Peking University

Center for Life Sciences

Peking University First Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Clarifying the immunoglobulin light chain variable gene usage in Chinese patients with renal AL amyloidosis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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