Association Between Cardiovascular Health (Lifes Crucial 9) and Stress Urinary Incontinence in Women: The Mediating Role of Oxidative Stress Factors (NHANES 2005-2018)

Ying Li,1, Haiyan Huang,1, Meizhu Lin,2 Xuanmo Fang,1 Lanping Huang,1 Minhua Ye,1 Wanqing Wang,1 Yang Yang,2 Xiaoyan Li2 1Department of Obstetrics 2Department of Obstetrics These authors contributed equally to this workCorrespondence: Yang Yang, Department of Obstetrics 95% confidence intervals (CI), 0.673– 0.993 and 0.600– 0.975, respectively]. Furthermore, RCS results suggested an approximately linear dose-response relationship between LC9 and the prevalence of SUI. Additionally, mediation analysis indicated that oxidative stress biomarkers, specifically bilirubin and uric acid, mediated the relationship between LC9 and SUI, with mediation proportions of 2.22% and 2.64%, respectively (P < 0.05).Conclusion: The present study suggests that higher LC9 scores, which represent ideal CVH, are significantly associated with reduced odds of SUI. Additionally, oxidative stress biomarkers may play a mediating role in this relationship.Keywords: life’s crucial 9, stress urinary incontinence, cardiovascular health, oxidative stress, NHANES