March 3, 2026Open Access

Dynamic functional connectivity changes in the triple networks in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes

Key Points

Cognitive impairment is linked to abnormal dynamic functional connectivity states in MELAS patients, highlighting neural network dysfunction.
The study identified significant temporal properties of dynamic functional connectivity in triple networks among MELAS patients.

Structured PICO

Population

Patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS)

Outcome

Temporal properties of dynamic functional connectivity (dFC) states within the triple networksurrogate

MELAS patients exhibit abnormal temporal properties of dynamic functional connectivity states within the triple network, providing insight into the neural mechanisms of their cognitive impairment.

Abstract

This study revealed abnormal temporal properties of dFC states within the triple network in MELAS patients, providing novel insights for understanding neural network mechanisms of their cognitive impairment.

Dynamic functional connectivity changes in the triple networks in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes

Key Points

Structured PICO

Abstract

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