Circulating Thrombospondin-2 Levels Reflect Hepatic Fibrosis Severity and Renal Dysfunction in a General Population: Uku Study | Synapse
March 3, 2026Open Access
Circulating Thrombospondin-2 Levels Reflect Hepatic Fibrosis Severity and Renal Dysfunction in a General Population: Uku Study
Key Points
Serum thrombospondin-2 levels correlate significantly with hepatic fibrosis severity and renal dysfunction.
In healthy individuals, higher TSP-2 levels indicate greater liver fibrosis, suggesting a key diagnostic role.
Analysis utilized serum biomarker measurements to evaluate liver and kidney health across a general population.
These findings highlight the diagnostic potential of TSP-2, but further research is needed to validate its clinical use.
Abstract
These findings suggest a significant association between serum TSP-2 levels and both liver fibrosis and renal dysfunction, even in a healthy Japanese general population.