March 3, 2026Open Access

Identification of small molecule inhibitors targeting FGFR through molecular docking-based screening

Key Points

The identified small molecule ZINC000101867325 inhibits FGFR signaling in colorectal cancer cell lines.
This compound displays superior bonding stability with FGFR1, FGFR2, and FGFR3 compared to other candidates.
Molecular docking-based screening was employed to predict the effectiveness of various small molecules against FGFRs.
This discovery highlights potential advancements in cancer treatment strategies using FGFR inhibitors.

Abstract

We predicted three small molecules targeting FGFRs, and ZINC000101867325 shows superior chemical bond types and stability with FGFR1/2/3, and inhibits FGFR signaling in CRC cell lines. This study provides novel FGFRs inhibitors, which enrich treatment strategies for cancers.

Identification of small molecule inhibitors targeting FGFR through molecular docking-based screening

Key Points

Abstract

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