March 3, 2026Open Access

Canonical and noncanonical NF-kappa B signaling in uveal melanoma: mechanisms, microenvironment, and therapeutic modulation

Key Points

Uveal melanoma malignancy requires canonical NF-κB signaling, affecting treatment options.
Noncanonical NF-κB signaling is associated with high-risk features in uveal melanoma.
Future studies should incorporate branch-specific genetic manipulations to refine therapeutic strategies.
The findings suggest a targeted approach to enhance treatment efficacy through understanding NF-κB pathways.

Abstract

NF-κB signaling, particularly the canonical branch, is required for UM malignancy, while noncanonical signaling is linked with high-risk features. Branch-specific genetic manipulations and clinically relevant models should be employed in future research to maximize therapeutic strategies.

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Cite This Study

Jalali et al. (Wed,) studied this question.

synapsesocial.com/papers/69a75c05c6e9836116a245b6 https://doi.org/https://doi.org/10.51329/mehdiophthal1534

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