The metastasis landscape of Clonorchis sinensis-associated hepatocellular carcinoma: an integrated multi-omics and clinical study | Synapse
March 3, 2026Open Access
The metastasis landscape of Clonorchis sinensis-associated hepatocellular carcinoma: an integrated multi-omics and clinical study
Key Points
HCC metastasis is promoted by Clonorchis sinensis infection, highlighting significant gene alterations.
Our analysis found notable epigenetic changes linked to increased metastasis in HCC.
Using an integrated multi-omics approach, we identified critical pathways influenced by the infection.
These findings may enable targeted early intervention strategies to combat HCC progression.
Abstract
Our study reveals that Cs infection promotes HCC metastasis through gene and epigenetic alterations, providing mechanistic insights and identifying potential targets for early intervention.