March 3, 2026

Gut Microbiota, Lipidome, and Metabolites Mediate Immune Dysregulation in Diabetic Microvascular Disease: A Two-sample Mendelian Randomization and Mediation Analysis

Key Points

Immune dysregulation is linked to gut microbiota and lipidome in diabetic microvascular disease.
Mediation analysis using Mendelian randomization reveals significant causal pathways among plasma metabolites.
Previous studies on metabolic pathways highlight the role of gut bacteria in influencing immune responses.
Identifying these pathways may enable therapeutic targets for treating immune-related complications.

Abstract

Using causal inference approaches, this study identifies immune cell-mediated mechanisms underlying DMiVD, involving gut microbiota, plasma lipids, and metabolites. The results suggest potential intervention targets for mechanistic studies and therapeutic development.

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Discussion

Authors

Jiaxing Zhao

Zenghui Liu

Lu Kuang

Journals

Endocrine Metabolic & Immune Disorders - Drug Targets

Actions

Institutions

Guangzhou Medical University

Mudanjiang Medical University

Twelfth Guangzhou City People's Hospital

References and Citations

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Gut Microbiota, Lipidome, and Metabolites Mediate Immune Dysregulation in Diabetic Microvascular Disease: A Two-sample Mendelian Randomization and Mediation Analysis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study