March 3, 2026Open Access

Anatomical evidence links the stomach to the central amygdala, a region responsive to local GLP-1R agonist induced feeding and nausea-like behaviors in male mice

Key Points

Gastric control is linked to the central amygdala's response to GLP-1R activation, impacting feeding behaviors.
Mice with activated GLP-1R in the CeA experienced reduced food intake and nausea-like symptoms—indicating significant regulatory roles.
Observational analysis reveals the central amygdala's involvement in gastric circuits through specific GLP-1R activation.
Understanding these linkages may highlight novel therapeutic targets for feeding problems and nausea.

Abstract

This study provides anatomical evidence that the CeA of male mice is involved in gastric regulatory circuits, and shows that the CeA responds to site-specific GLP-1R activation to induce hypophagia and nausea-like behaviors.

Anatomical evidence links the stomach to the central amygdala, a region responsive to local GLP-1R agonist induced feeding and nausea-like behaviors in male mice

Key Points

Abstract

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