Diurnal variation of cisplatin-induced anti-tumor effect and renal toxicity in mice bearing human colon cancer cells

Key Points

• Cisplatin shows time-dependent variation in its anti-tumor effect, emphasizing the importance of treatment timing.
• The observed renal toxicity changes with diurnal patterns, highlighting potential protective strategies based on time.
• Assessment involved modeling human colon cancer cells in mice to explore treatment responses across different times of day.
• The findings may enhance treatment protocols, but preclinical mouse model limits warrant caution on human applicability.