KCNB1 mutation impairs neuronal differentiation by disrupting gene expression temporal regulation and neuron-specific pathways

Key Points

• Neuronal differentiation is significantly impaired by low expression of KCNB1, showing a disruption in maturation.
• The temporal pattern of gene expression, critical for neuronal development, is altered due to KCNB1 mutation.
• Assessment of gene regulation indicates that neuron-specific pathways are disrupted in this context.
• This study highlights potential targets for therapeutic intervention in neurodevelopmental disorders associated with KCNB1.

Abstract