Functional group orientation-dependent conformational polymorphism in 5-fluorocytosine–L-malic acid cocrystals

Key Points

• Conformational polymorphism indicates molecular flexibility in cocrystals composed of 5-fluorocytosine and l-malic acid, advancing material design.
• Key findings show that varying functional group orientations lead to different crystal arrangements; notably, two distinct polymorphs were identified.
• Analysis utilized crystallography techniques, revealing previously unexplored interactions between functional groups in the cocrystal formation.
• The work supports the potential for tailored cocrystal designs by manipulating functional group orientation, with implications for drug development.