Nanotechnology has significantly advanced the field of drug delivery by enabling the development of systems that offer precise, controlled, and site-specific transport of therapeutic agents. Among the various nanocarriers, polymeric nanoparticles (PNPs) have gained substantial attention due to their biodegradability, biocompatibility, and the ability to overcome key physiological barriers that limit the effectiveness of conventional drug delivery methods. PNPs can encapsulate a wide variety of therapeutic agents-including small molecules, proteins, and nucleic acids-and facilitate their controlled and sustained release, thereby improving therapeutic outcomes while minimizing systemic toxicity and adverse effects. The unique physicochemical properties of polymeric nanoparticles, such as nanosize, surface charge, morphology, and surface functionalization, allow for enhanced bioavailability, cellular uptake, and targeted delivery to specific tissues or cells. These characteristics make PNPs especially suitable for treating complex diseases such as cancer, neurodegenerative disorders, and infections, where targeted and efficient drug delivery is essential. This review comprehensively explores the synthesis techniques of PNPs, including solvent evaporation, nanoprecipitation, emulsification, and polymerization methods, and discusses key parameters affecting nanoparticle formulation. It also highlights advanced characterization tools used to determine particle size, surface charge, morphology, stability, and drug loading efficiency. Moreover, the paper delves into the biomedical applications of polymeric nanoparticles, with particular emphasis on brain targeting, cancer therapeutics, and regenerative medicine. Strategies such as surface modification, ligand functionalization, and stimuli-responsive systems are discussed for enhancing targeted delivery and therapeutic efficacy. Despite promising advancements, challenges related to large-scale production, regulatory compliance, long-term safety, and clinical translation remain. The review concludes by presenting future prospects and innovations in polymeric nanocarrier systems, emphasizing their potential to transform modern medicine by enabling personalized, efficient, and safer therapeutic interventions.
Lal et al. (Mon,) studied this question.