March 3, 2026Open Access

Ivabradine Preserves Cardiac Structure and Reduces Cell Death in Four Dogs With Preclinical Mitral Valve Disease

PPPrapawadee PirintrChulalongkorn University VLVudhiporn LimprasutrChulalongkorn University ARAnudep RungsipipatChulalongkorn University

Key Points

Ivabradine treatment significantly reduced heart rate, which supports optimal cardiac function while preventing damage.
Chronic therapy resulted in lower rates of apoptosis, indicating reduced cell death in the cardiac tissue.

Structured PICO

Does chronic ivabradine treatment reduce cardiac structural remodeling and apoptosis in dogs with preclinical mitral valve disease?

Population

4 dogs with preclinical myxomatous mitral valve disease (MMVD stage B2)

Intervention

Chronic ivabradine treatment

Outcome

Heart rate, cardiac structural remodelling, apoptosis, and cardiac functionsurrogate

Ivabradine demonstrates potential as a therapeutic option for asymptomatic canine heart disease by preserving cardiac structure and reducing cell death.

Abstract

Chronic ivabradine treatment lowered HR and reduced cardiac structural remodelling and apoptosis without impairing cardiac function in dogs with MMVD stage B2. These findings support the potential of ivabradine as a therapeutic option for asymptomatic canine heart disease.

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