The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15

Key Points

• Viral replication is significantly restricted by the action of DDX6 on viral NP and ISG15 modulation.
• The study found that DDX6 reduces viral NP levels and affects immune response pathways.
• Analysis of antiviral mechanisms highlighted DDX6’s role in enhancing host defense against avian influenza.
• Further work is needed to explore DDX6 as a therapeutic target in treating influenza infections.