Metal–atovaquone complexes with antiplasmodial activity: chemical reactivity and structure–activity relationships

Key Points

• Antimalarial activity was potent in metal complexes with atovaquone, indicating their therapeutic potential.
• Complexes featuring silver, zinc, and copper exhibited significant selectivity against malaria parasites.
• Observation leveraged chemical reactivity to explore structure-activity relationships in the complexes.
• The findings highlight the need for further studies on metal complexes for developing effective antimalarial treatments.