The PROTECT trial: Effect of titrated versus conventional induction of general anaesthesia using a target-controlled infusion system on haemodynamics in patients undergoing non-cardiac surgery – protocol for a multicentre, expertise-based randomised controlled trial

Key Points

• Patients undergoing non-cardiac surgery experience differences in haemodynamics with titrated induction.
• The trial targets how titrated induction impacts blood flow and stability during surgery, aiming for better outcomes.
• Randomized controlled trial protocol will assess the effectiveness across multiple healthcare settings.
• Results may enhance anaesthesia practices, but multicentre validation is crucial for wider application.