Malignant pleural mesothelioma in a young patient with neurofibromatosis 2 and acquired BAP1 loss: A case report

Key Points

• Malignant pleural mesothelioma was diagnosed in a young patient, emphasizing its rare occurrence in this age group.
• Significant loss of BAP1, a critical tumor suppressor, was observed, possibly indicating a genetic predisposition to the cancer.
• Pathological features of the tumor were analyzed, revealing associations with neurofibromatosis 2 and acquired genetic alterations.
• Further investigation of BAP1's role in mesothelioma could provide insights into targeted therapies and genetic screening.