SIRT3 ameliorates hepatic inflammation, oxidative stress, and fibrosis in HFD- or MCD diet-fed mice

Key Points

• SIRT3 treatment significantly reduces hepatic inflammation and oxidative stress in mice.
• Liver fibrosis outcomes improved in mice fed high-fat or methionine-choline deficient diets.
• Assessment using diet-induced mouse models highlights the effects of SIRT3 on liver health.
• Findings suggest potential strategies for managing liver diseases associated with diet.