A subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor

Key Points

• The novel negative allosteric modulator selectively targets the GluN1/GluN3A glycine-activated receptor, altering its activity.
• Initial tests show a significant modulation effect on receptor function, suggesting a promising therapeutic application.
• Utilizing a new approach, the analysis of the receptor interactions sheds light on selective modulation dynamics.
• Impacts on receptor activity could lead to advancements in treatment strategies for neurological disorders.