March 3, 2026Open Access

Depression mediated sleep disturbances and cognitive decline in Parkinson’s disease patient

Key Points

Cognitive decline is linked to sleep disturbances in Parkinson’s disease patients, influencing overall quality of life.
Notably, depression contributes to daytime sleepiness, exacerbating cognitive issues and complicating treatment approaches.
Analysis of sleep-related cognitive decline focuses on distinct neurobehavioral mechanisms affecting both mood and REM sleep disorder.
These insights underscore the need for tailored interventions to effectively target these specific pathways in Parkinson’s disease.

Abstract

Divergent neurobehavioral mechanisms underlie sleep-related cognitive decline in PD: daytime sleepiness operates through mood dysregulation, while rapid eye movement sleep disorder involves additional direct neural insult. Interventions targeting these pathways may require distinct strategies.

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Discussion

Journals

Frontiers in Neuroscience

Institutions

Zhengzhou University

Xuzhou Medical College

Nanjing University of Chinese Medicine

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