Persulfate-driven free radical depolymerization of fucosylated chondroitin sulfate and intrinsic Xase inhibition of the resulting oligosaccharides

Key Points

• Oligosaccharides resulted from the persulfate-driven depolymerization exhibit intrinsic xase inhibition.
• This depolymerization generates free radicals, which are crucial in altering the molecular characteristics of the chondroitin sulfate.
• The study employs a systematic approach to evaluate the interaction between oligosaccharides and enzyme activity.
• Findings indicate potential therapeutic applications for modified oligosaccharides in anticoagulation therapies.