The role of gasdermin D-mediated pyroptosis in hepatic ischemia–reperfusion injury and prediction of the therapeutic natural products

Key Points

• Pyroptosis significantly contributes to hepatic ischemia-reperfusion injury, suggesting a critical role in liver damage.
• Key evidence includes elevated markers of liver injury following ischemia and reperfusion events.
• Assessment of gasdermin D's role indicates it mediates inflammatory cell death in response to ischemic conditions.
• Findings highlight the potential of therapeutic natural products to target pyroptosis and reduce liver injury during reperfusion.