CircMkrn2 facilitates the progression of atrial fibrillation via sponging miR-10b-5p

Key Points

• Atrial fibrillation progression is facilitated by the sponging action of Circ_Mkrn2 on miR-10b-5p, signaling a new molecular pathway.
• Key evidence shows that manipulating Circ_Mkrn2 levels significantly alters miR-10b-5p activity, impacting atrial fibrillation phenotypes.
• Analysis demonstrates a significant interaction between Circ_Mkrn2 and miR-10b-5p in patient-derived cardiac tissues.
• These findings highlight the potential role of Circ_Mkrn2 as a therapeutic target for preventing or treating atrial fibrillation.