Synergistic Efficacy of Lactobacillus plantarum Supernatant-Preconditioned BM-MSCs in Alleviating Depression, Anxiety-Like Behavior, and Memory Impairment in a Rat Stress Model by Suppressing the NF-κB Pathway

Key Points

• Alleviation of depression and anxiety-like behavior occurs through NF-κB pathway suppression in the model.
• Rats treated with Lactobacillus plantarum preconditioned BM-MSCs showed significant behavioral improvements after six weeks.
• Analysis involves a rat stress model assessing the effects on memory impairment and behavioral responses.
• Supports the potential for microbiome modulation to treat mood disorders, but further studies are needed.