4,4′-dimethoxychalcone exerts neuroprotective effects in Alzheimer's disease mice by activating the Keap1/Nrf2 signaling pathway

Key Points

• Neuroprotection was observed through activation of the keap1/nrf2 signaling pathway, reducing oxidative stress.
• Mice treated with 4,4′-dimethoxychalcone showed significant improvements in cognitive function and behavior.
• Observational analysis across a mouse model of Alzheimer's disease evaluated the effects of 4,4′-dimethoxychalcone.
• Highlighting the potential for new treatment strategies targeting oxidative stress in Alzheimer's disease.],