Metastatic organotropism in peritoneal metastasis: Paget’s hypothesis revisited

Key Points

• Peritoneal metastasis is influenced by organotropism, revealing patterns that align with Paget's hypothesis.
• Key biological factors, including the tumor microenvironment, are critical in determining metastatic sites.
• The analysis revisits Paget's hypothesis, suggesting a biological basis for preferential organ involvement in metastasis.
• Understanding these mechanisms may enable more effective targeting strategies for metastatic cancers.