A structural overview of G-protein-coupled receptors in neurological disorders

Key Points

• G-protein-coupled receptors play a critical role in neurological disorders and their signal transduction pathways.
• In particular, alterations in receptor structure impact their function and contribute to various pathophysiological states.
• The observational analysis includes insights from numerous studies across different neurological disorders, pooling data on receptor function.
• Understanding these mechanisms may enable the development of new therapeutic strategies to address chronic neurological issues.