Macrophage-derived S100A9 drives liver fibrosis in Echinococcus multilocularis infection by up-regulating secreted protein acidic and rich in cysteine (SPARC) in hepatic stellate cells | Synapse
March 3, 2026
Macrophage-derived S100A9 drives liver fibrosis in Echinococcus multilocularis infection by up-regulating secreted protein acidic and rich in cysteine (SPARC) in hepatic stellate cells
Key Points
Liver fibrosis is driven by macrophage-derived S100A9 during Echinococcus multilocularis infection, affecting liver health.
S100A9 significantly up-regulated the secreted protein acidic and rich in cysteine (SPARC), contributing to fibrotic changes in liver cells.
Assessment involved cellular interactions between macrophages and hepatic stellate cells in response to parasitic infection.
Targeting S100A9 may help develop new treatments for liver fibrosis linked to Echinococcus multilocularis.