Commensal-myeloid crosstalk in neonatal skin regulates interleukin-1 signaling and cutaneous type 17 inflammation

Key Points

• Crosstalk between commensal and myeloid cells significantly regulates interleukin-1 signaling in the skin.
• Key findings indicate that altered interleukin-1 signaling may lead to heightened type 17 inflammation.
• This observational analysis explores interactions in the neonatal skin environment, emphasizing the role of microbiome components.
• Significant implications exist for potential therapeutic strategies targeting crosstalk pathways in skin inflammation.